Studies on Leukocyte Antibodies, with Special Reference to the Production of Antibodies Subsequent to Blood Transfusion.

The importance of blood transfusion in stimulating the production of most leuko-agglutinins is established beyond all doubt. Among 60 leuko-agglutinating sera studied by Dausset, 90 per cent were from patients who had received multiple (average of 22) transfusions. Brittingham, Andre et al. and Payne also noted a high degree of correlation. Other than leuko-agglutinins, various types of homologus leukocyte antibodies have been found in human sera, but have been much less studied to date than the agglutinins. The present report mainly shows the occurance of such antibodies, as leuko·agglutinins, complement-fixing leukocyte antibodies, incomplete antileukocyte antibodies by means of the antihuman-globulin consumption test leukocyte phagocytosis inhibiting factor and leuko-precipitins subsequent to transfusion. Transfusion reactions associated with those antibodies were also investigated. Experimental studies on the antigenic differences and similarities between different morphologic parts of the leukocyte with special reference with the antigenicity of neutrophilic granules, and also immunoagranulocytosis.